THE GERMICIDAL AND HEMOLYTIC ACTION OF α-BROM SOAPS

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The Germicidal and Hemolytic Action of Α-brom Soaps

1. The soaps of the alpha-brom fatty acids are usually more germicidal than the unsubstituted soaps. Only when B. typhosus was the test organism was there no increase in germicidal action. 2. For any test organism, germicidal action of the brominated soaps increases rapidly with increasing molecular weight up to a certain point, then diminishes. This is likewise true of the hemolytic titer. The...

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THE GERMICIDAL AND HEMOLYTIC ACTION OF a-BROM

This paper is the first of a contemplated series of papers describing the germicidal action of various soap derivatives. The ordinary soaps are salts of fatty acids, the fatty acid radical consisting of a straight chain of carbon atoms to the first of which two oxygen atoms are attached, while the remainder are united to each other and to hydrogen. I t is possible to replace one or more of thes...

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The Germicidal Action of Α-mercapto and Α-disulfo Soaps

1. Certain of the alpha-mercapto soaps and alpha-disulfo soaps are powerful germicides. 2. In the alpha-mercapto series, those soaps with 12 and 14 carbon atoms are most germicidal. In the disulfo series, the dicaprate, dilaurate, and dimyristate are most germicidal. The optimum number of carbon atoms varies with the test organism used. 3. These soaps, like others previously studied, show a mar...

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The Effect of Serum upon the Germicidal Action of Soaps

1. Far more information about the effect of serum or other substances upon the germicidal action of soaps can be obtained by determining the germicidal titers over a wide range of pH than by determining the titer at a single pH. In this way a characteristic curve for each test substance is obtained. 2. The curve for a particular concentration of serum bears a definite relationship to the curve ...

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THE EFFECT OF THE pH ON THE GERMICIDAL ACTION OF SOAPS

1. The effect of the pH on the germicidal action of soaps has been studied. The lower members of the series were found to be most active in acid solution; the higher members, in alkaline. The point of transition varied with the test organism used. 2. This is probably due to the effect of the pH on the dissociation residue and on the solubility of the soap. The dissociation residue may affect th...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1929

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.49.1.53